Sexual dysfunction among perimenopausal women attending a tertiary care centre: A descriptive cross-sectional Study

Shreyashi Aryal, Kristina Shakya, Jiya Acharya — Sun, 26 Oct 2025 00:00:00 +0545

Introduction: The perimenopausal phase involves declining estrogen and ovarian function, causing changes like weakened pelvic muscles and vaginal thinning that often result in sexual dysfunction. The Female Sexual Function Index-6 is a validated tool commonly used to assess these female sexual function issues for early identification and management.
Objectives: This study aimed to determine the prevalence of sexual dysfunction using the Female Sexual Function Index-6 among perimenopausal women attending the Obstetrics and Gynaecology outpatient department.
Methodology: A descriptive cross-sectional study was conducted among perimenopausal women visiting the Obstetrics and Gynaecology outpatient department in a tertiary care centre. Ethical approval was obtained from the Institutional Review Committee. Women with incomplete questionnaires, those with diagnosed psychiatric disorders, unable to provide consent to participate, women with cervical pathology like cervical polyp or carcinoma, malignancies or pelvic surgery, women under hormone replacement therapy and those with surgical menopause were excluded. A convenience sampling technique was used. Point estimate and confidence interval were calculated for binary data.
Results: Among 60 perimenopausal women, the mean total Female Sexual Function Index score was 11.77±6.44, indicating a high prevalence of sexual dysfunction across all six domains. Sexual function was poorer among women whose partners worked abroad, with only 25.21% of the FSFI score. The orgasm domain was the most impaired (1.25±1.22), followed by desire (1.43±0.74) and arousal (1.45±1.08).
Conclusion: It was found that a larger number of perimenopausal women had sexual dysfunction, with the lowest score in orgasm and desire.

Clinical profile, severity, and outcomes of acute pancreatitis among patients visiting a tertiary care center in Eastern Nepal

Khushboo Priya, Rishab Shrestha, Dipak Kumar Sah, Rajan kumar Thadhiya — Sun, 26 Oct 2025 00:00:00 +0545

Introduction: Acute pancreatitis (AP) is a common gastrointestinal emergency with variable clinical presentation and outcomes. Severity indices such as the Modified CT Severity Index are important tools for predicting complications and outcomes.
Objective: To evaluate the clinical profile, severity and outcomes of patients with acute pancreatitis at a tertiary care center in Eastern Nepal.
Methodology: A descriptive cross-sectional study was conducted at Nobel Medical College Teaching Hospital, Biratnagar over a period of one year among 90 patients using consecutive sampling. Patients aged ≥18 years fulfilling at least two of these criteria: typical abdominal pain, ≥3 times elevated serum amylase/lipase, or imaging features of acute pancreatitis were included. Data were analyzed using IBM SPSS Statistics for Windows version 25 with descriptive statistics to summarise baseline characteristics and chi-square or Fisher’s exact tests to see the associations between disease severity and outcomes.
Results: The mean age of patient was 44.8 ± 15.9 years, with a male predominance 51 (57%). Alcohol 39 (43%) and gallstones 30 (33%) were the leading causes. Based on the Modified CT Severity Index, 13 (20%) of cases were mild, 38 (58%) moderate, and 15 (23%) severe. Complications occurred in 42 (47%) of patients more than half those were peripancreatic fluid collection. Overall mortality was 5 (6%,) all within the severe group. Disease severity showed a significant association with mortality (p < 0.001).
Conclusion: Acute pancreatitis in Eastern Nepal predominantly affects middle-aged males. A substantial proportion present with moderate-to-severe disease and notable mortality, underscoring the need for early severity assessment and improved critical care facilities.

Journal of Kathmandu Medical College

Sexual dysfunction among perimenopausal women attending a tertiary care centre: A descriptive cross-sectional Study

Clinical profile, severity, and outcomes of acute pancreatitis among patients visiting a tertiary care center in Eastern Nepal